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pentobarbital will minimize the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will decrease the extent or result of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with potent CYP3A4 inducers will not be suggest